Daniel J Brat Selected Research

ErbB Receptors (EGF Receptor)

12/2016	EGFR and C/EBP-β oncogenic signaling is bidirectional in human glioma and varies with the C/EBP-β isoform.
9/2013	Tumor-infiltrating lymphocytes in glioblastoma are associated with specific genomic alterations and related to transcriptional class.
7/2013	Blockade of glioma proliferation through allosteric inhibition of JAK2.
10/2012	Glioblastoma occurring at the site of a previous medulloblastoma following a 5-year remission period.
7/2009	Chordoid glioma: a case report and molecular characterization of five cases.
3/2009	Epidermal growth factor receptor and PTEN modulate tissue factor expression in glioblastoma through JunD/activator protein-1 transcriptional activity.
2/2009	Vasculostatin inhibits intracranial glioma growth and negatively regulates in vivo angiogenesis through a CD36-dependent mechanism.
11/2005	Clarifying the diffuse gliomas: an update on the morphologic features and markers that discriminate oligodendroglioma from astrocytoma.
7/2004	Delivery systems and molecular targets of mechanism-based therapies for GBM.
10/2003	Alterations in molecular pathways of diffusely infiltrating glial neoplasms: application to tumor classification and anti-tumor therapy (Review).

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Daniel J Brat Research Topics

Disease

87	Neoplasms (Cancer) 02/2024 - 01/2002
54	Glioma (Gliomas) 02/2024 - 01/2003
40	Glioblastoma (Glioblastoma Multiforme) 12/2023 - 01/2003
16	Hypoxia (Hypoxemia) 12/2023 - 01/2002
13	Astrocytoma (Pilocytic Astrocytoma) 05/2018 - 03/2002
12	Brain Neoplasms (Brain Tumor) 02/2023 - 10/2003
9	Oligodendroglioma 01/2020 - 11/2005
6	Meningioma (Meningiomas) 04/2024 - 11/2004
6	Thrombosis (Thrombus) 01/2022 - 04/2004
6	Necrosis 07/2014 - 01/2002
5	Carcinogenesis 01/2023 - 04/2003
5	Neoplasm Metastasis (Metastasis) 01/2023 - 09/2008
5	Medulloblastoma 10/2012 - 11/2004
3	Pancreatic Neoplasms (Pancreatic Cancer) 01/2023 - 04/2015
3	Breast Neoplasms (Breast Cancer) 01/2023 - 01/2014
3	Central Nervous System Neoplasms 01/2022 - 03/2002
3	Pituitary Neoplasms (Pituitary Adenoma) 05/2013 - 07/2003
3	Retinoblastoma (Glioblastoma, Retinal) 07/2004 - 01/2002
2	Carcinoma (Carcinomatosis) 01/2023 - 04/2008
2	Lymphoma (Lymphomas) 11/2020 - 04/2008
2	Alzheimer Disease (Alzheimer's Disease) 01/2019 - 10/2018
2	Disease Progression 01/2018 - 04/2004
2	Brain Injuries (Brain Injury) 11/2017 - 10/2005
2	Adenocarcinoma 06/2016 - 01/2015
2	Leukemia 01/2015 - 08/2014
2	Tuberous Sclerosis (Bourneville's Disease) 09/2009 - 02/2005
2	Hyperplasia 04/2008 - 01/2002
1	Hematologic Neoplasms (Hematological Malignancy) 01/2023
1	alpha-Thalassemia 01/2023
1	Circulating Neoplastic Cells 01/2023
1	Intellectual Disability (Idiocy) 01/2023
1	Diffuse Intrinsic Pontine Glioma 10/2022
1	Brain Stem Neoplasms (Brain Stem Tumor) 10/2022

Drug/Important Bio-Agent (IBA)

27	Proteins (Proteins, Gene)FDA Link 01/2023 - 01/2003
18	Biomarkers (Surrogate Marker)IBA 02/2023 - 12/2006
12	ErbB Receptors (EGF Receptor)IBA 12/2016 - 01/2002
10	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 04/2015 - 01/2002
9	Thromboplastin (Tissue Factor)IBA 04/2015 - 04/2004
8	Isocitrate Dehydrogenase (Isocitrate Dehydrogenase (NAD+))IBA 09/2022 - 03/2013
7	RNA (Ribonucleic Acid)IBA 01/2022 - 03/2002
7	DNA (Deoxyribonucleic Acid)IBA 10/2021 - 09/2010
7	Transcription Factors (Transcription Factor)IBA 01/2015 - 12/2004
6	Messenger RNA (mRNA)IBA 01/2023 - 01/2003
5	CytokinesIBA 12/2016 - 01/2002
4	Phosphotransferases (Kinase)IBA 01/2019 - 09/2012
4	Glial Fibrillary Acidic ProteinIBA 11/2017 - 06/2002
4	Tumor Suppressor Protein p14ARF (p14ARF)IBA 03/2014 - 01/2003
4	Mucin-1 (CA 15-3 Antigen)IBA 07/2009 - 06/2002
4	Complementary DNA (cDNA)IBA 07/2006 - 03/2002
3	Temozolomide (Temodar)FDA LinkGeneric 10/2016 - 12/2010
3	Genetic Markers (Genetic Marker)IBA 06/2016 - 07/2003
3	AntibodiesIBA 04/2015 - 05/2009
3	LigandsIBA 01/2015 - 03/2009
3	epidermal growth factor receptor VIIIIBA 07/2013 - 02/2009
3	Interleukin-8 (Interleukin 8)IBA 01/2012 - 04/2005
3	Formaldehyde (Formol)FDA Link 03/2011 - 03/2006
3	ParaffinIBA 03/2011 - 03/2006
3	Transcription Factor AP-1 (Transcription Factor AP 1)IBA 03/2009 - 04/2005
2	platelet-derived growth factor AIBA 01/2023 - 01/2022
2	Cyclin-Dependent Kinases (cdk Proteins)IBA 11/2022 - 09/2009
2	CoagulantsIBA 01/2022 - 11/2017
2	EnzymesIBA 10/2021 - 11/2015
2	Alkylating AgentsIBA 12/2019 - 12/2010
2	Amyloid (Amyloid Fibrils)IBA 01/2019 - 10/2018
2	Phosphogluconate Dehydrogenase (Dehydrogenase, Phosphogluconate)IBA 11/2015 - 08/2014
2	phenylalanyl-phenylalanyl-arginine chloromethyl ketoneIBA 04/2015 - 01/2014
2	Paclitaxel (Taxol)FDA LinkGeneric 04/2015 - 01/2014
2	Telomerase (Telomerase Reverse Transcriptase)IBA 01/2015 - 02/2005
2	Epidermal Growth Factor (EGF)IBA 08/2014 - 03/2009
2	Serine Proteases (Serine Protease)IBA 03/2014 - 07/2004
2	LuciferasesIBA 01/2014 - 07/2006
2	Adenosine (Adenocard)FDA LinkGeneric 07/2013 - 07/2004
2	Pituitary HormonesIBA 05/2013 - 07/2003
2	Contrast MediaIBA 05/2013 - 04/2013
2	Caspase 3 (Caspase-3)IBA 09/2011 - 10/2005
2	Matrix Metalloproteinases (MMPs)IBA 09/2011 - 04/2005
2	Therapeutic UsesIBA 07/2007 - 12/2004
2	NF-kappa B (NF-kB)IBA 07/2006 - 04/2005
2	factor AIBA 10/2005 - 12/2004
2	Erythropoietin FDA Link 10/2005 - 04/2005
2	Hypoxia-Inducible Factor 1IBA 04/2005 - 02/2004
2	Peptide Hydrolases (Proteases)FDA Link 06/2004 - 02/2004
2	S100 Proteins (S 100 Protein)IBA 10/2003 - 06/2002
1	Proto-Oncogene Proteins B-rafIBA 02/2024
1	CreatineIBA 12/2023
1	Deubiquitinating EnzymesIBA 01/2023
1	Trastuzumab (Herceptin)FDA Link 01/2023
1	Ataxin-3IBA 01/2023
1	Immune Checkpoint InhibitorsIBA 01/2023
1	Histones (Histone)IBA 01/2023
1	Chimeric Antigen ReceptorsIBA 01/2023
1	Ubiquitin-Specific ProteasesIBA 01/2023
1	dipinacoline glutamateIBA 10/2022

Therapy/Procedure

37	Therapeutics 04/2024 - 01/2002
9	Radiotherapy 12/2023 - 03/2004
5	Drug Therapy (Chemotherapy) 01/2023 - 06/2004
4	Immunotherapy 01/2023 - 01/2019
4	Precision Medicine 11/2022 - 01/2016
2	Aftercare (After-Treatment) 10/2012 - 10/2005
1	Adjuvant Radiotherapy 04/2024